Male albino rabbits (n = 6) weighing 1.2-1.6 kg, supplemented with high cholesterol diet (400 mg/kg) for 12 weeks were used in the experiment. Blood samples were collected at day 0, week 4, and week 10 to measure serum lipid profile, nitrate/nitrite (NOx), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels. After the treatment period, the plasma antioxidant enzymes and lipid profiles were determined. The aim of this work was to study the response of the intracellular machinery that regulates testicular cholesterol levels to lipid stress caused by a diet enriched in saturated fats in rabbits. Twenty-nine adult male rabbits (weighing 2.2 ± 0.5 kg) were divided into four groups that were fed a regular chow as control group (n = 8), a normal diet plus SP treatment (n = 4), a HCD as high lipid diet group (n = 12) and a HCD plus SP treatment group (n = 5) respectively. Total Cholesterol going UP with Iodine at Iodine ...Switching diet from white to black rice can modulate the ...What Are the Benefits of Wheatgrass for Cholesterol and ... LDL: 18-25 nm. 3 1. Fifteen rabbits were distributed into three groups of five each [normal diet, hypercholesterolemic diet (1% cholesterol) and hypercholesterolemic diet (1% cholesterol) supplemented with 5% NS]. Methods: White male rabbits were fed either a high-cholesterol diet (HC; 1% cholesterol, n = 6) or control diet (c, n = 6) for one month. 12 Herbs To Lower Cholesterol Quickly: Use Them Now! The serum levels of Cholesterol, LDL, HDL, NOx, insulin and CRP were measured before and after study. In rabbits fed a high-cholesterol diet, we evaluated the effects of the combination therapy on atherosclerotic plaques, lipid profiles, blood glucose levels, liver and kidney functions. Effects of combination therapy on cholesterol efflux and the expression of related transporters were studied in vitro. cholesterol amounts daily. Thirty two male rabbits were randomly divided into four groups . Rabbits were fed either normal chow or atherogenic diet for 10 weeks. Eighteen rabbits were randomly divided into three groups (n=6 for each). The initiating events of the disease are similar to those in humans. Methods: The rabbits were assigned to four groups: Group I, regular diet (control); Group II, 5% flaxseed oil in regular diet; Group III, 0.5% cholesterol diet; Group IV, diet containing 0.5% cholesterol and 5% flaxseed oil. Means for normal rabbits depicted maximum cholesterol level as 73.02 ± 3.69 mg/dL in (N group) that significantly reduced to 70.09 ± 3.16 mg/dL (NRCE group . The vaccine consists of a rabbit IgG Fc domain for antigen delivery to antigen-presenting cells fused to a linear array of 6 repeats of a CETP epitope to efficiently activate B cells. They ran her blood for her pain meds and had to send to a lab since there was a lot of fat in her blood / high cholesterol. Excess fat ingestion in one's daily diet would raise the blood cholesterol and TG levels, which are important risk factors of CVD. N Vatandoust, F Rami, AR Salehi, S Khosravi, G Dashti, G Eslami, . Blood samples were taken from the rabbits on baseline, 14th day, 36th day and 72nd day and the serum was used to determine levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and high density lipoprotein cholesterol (HDL-C . Values also be high if the rabbit is not eating enough, but this is a sign of advanced hepatic lipidosis and has a poor prognosis. Thirty rabbits were divided into three groups: one on a normal diet, one on a high-fat diet and one on a high-fat diet with wheatgrass. In order to assess the impact of functional rabbit meat on human blood lipid profile, a study trial was conducted. The effects of dietary flax seed on a high cholesterol diet induced atherosclerosis, lipid profile and OFR-producing activity of PMNLs (PMNL-CL) were investigated in rabbits. Distilled water was used as vehicle for both rosuvastatin and curcumin. Rabbits were fed either normal chow or atherogenic diet for 10 weeks. A total of 150 weanling New Zealand White (NZW) male rabbits were randomly allotted to six dietary treatment groups: (1 . Blood samples were collected at day 0, week 4, and week 10 to measure serum lipid profile, nitrate/nitrite (NOx), lactate . Lipid profile and quantification of MPs positive for Mycoplasma pneumoniae and oxidized LDL antigens were carried out. The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-rich diet. experimental diet fed to the rabbits. Utilization of linseed in the feed of rabbits significantly affected the pH, protein, fat, textural and concentration of polyunsaturated fatty acids. Korean Red Ginseng. Average blood cholesterol levels of animals on the three diets were: cholesterol (13.45 mmol/L), Finally, the groups were compared considering serum lipid profile . A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits Combination of atorvastatin and guggul was comparable to their monotherapies in improving lipid profile. - Volume 69 Issue OCE2. In the evening I feed RMB, usually chicken feet/necks/rabbit feet/whole prey etc, with hemp oil and organic canned pumpkin. To provide a basis for establishing better animal models with hyperlipidemia by comparing the effects of two different high-fat diets on blood lipids of rats. INTRODUCTION: Recent studies indicate that endothelin-1 (ET-1) and abnormality in the transfer of calcium ions have a role in the . We Effects of dietary red clover on blood factors and cardiovascular fatty streak formation in hypercholesterolemic rabbits. Group (IV) (Cholesterol and Curcumin treated): Rabbit were received curcumin 0.2% added with corn pellets and 2% cholesterol diet. Sitagliptin (6 mg/kg/twice daily) was given orally for 6 weeks starting from week 4. Andrology Atherosclersis Osteoporosis Fertility and infertility. Serum Lipid Profile. The group receiving wheatgrass with the high-fat diet had reduced total cholesterol and high-density lipoprotein, the "good" cholesterol. In addition to current therapeutic strategies, a lot of work is being done on nutraceutical management of this condition. View 0 peer reviews of Effect of Flaxseed on Lipid Profile, Antioxidants and PPAR-alpha Gene Expression in Rabbit Fed Hypercholesterolemic Diet on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes. Thirty rabbits divided into six groups of five animal (group= 5) each: group 1 = normal control,group 2 = cholesterol diet/high fat diet group only (HFD), group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. 3.1 Use this herb's seeds for the treatment of hyperlipidemia. Fasting plasma samples were estimated for homocysteine and lipid profile. The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-rich diet. Group (III) (Cholesterol and Rosuvastatin treated): Rabbits were received rosuvastatin (2.5 mg/kg/day) and 2% cholesterol diet with tab water. 3.2 From herbs to lower cholesterol quickly: 4 2. Materials and Methods: One hundred rabbits were divided into 4 equal groups. Methods. After 8 weeks on high-cholesterol diet, the experimental model group animals were divided into two groups: high-cholesterol diet group (HCD, ) and Simvastatin group (HCD + Simvastatin, ). Serum Lipid Profile. The increase of lipids and ET-1 in the renal artery and plasma with a high-cholesterol diet is not linked to the early stages of atherosclerotic plaque formation and amlodipine can reduce levels ofET-1 and lipids, but the mechanisms remain to be determined. It is consumable at concentrations of 3-9%. Groups of rabbits were fed for six weeks various diets: standard died + ethanol, high-cholesterol diet and a high-cholesterol + ethanol one. The role of Zn-supplemented with high cholesterol diet on serum and whole blood rheological properties of rabbits fed a high cholesterol diet July 2015 Atherosclerosis 241(1):e194 A group of twenty eight male rabbits was divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1% (w/w) dandelion leaf group, and a high-cholesterol diet with 1% (w/w) dandelion root group. Group III rabbits fed with 1% cholesterol enriched diet together with glimepiride (0.1 mg/kg once daily before morning feed for 10 week). with disturbed cholesterol metabolism such as those lacking either the LDL receptor (Ldlr) or apolipoprotein E (apoe). The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-rich diet. Cholesterol and triglycerides were determined in the whole serum and in lipoprotein fractions. All three groups of rabbits consumed the same amount of calories regardless of diet and gained body weight similarly (Supplementary Fig. gholam reza dashti. Switching diet from white to black rice can modulate the lipid profile and oxidative stress in rabbits? A physiological atherogenic human diet consists of 0.1% cholesterol, fat, as well as high levels of methionine, which is the precursor to homocysteine. Rabbits fed HCD were chosen as an atherosclerotic animal model in the present study. The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-rich diet. 30 male Wistar rats were randomly . Nigella Sativa. Nifedipine was shown to improve hypertension, lipid profile as . The aim of this study was to investigate the pleotropic effects of an extract of a traditional herb, Tribulus terrestris (TT), on the lipid profile and vascular endothelium of the abdominal aorta in New Zealand rabbits fed a cholesterol-rich diet. Accumulation of total cholesterol (TC), cholesteryl esters (CE), triacylglycerols (TG) and free fatty acids (FFA) in the aorta of rabbits fed a reference diet without addition of cholesterol (NC), a high cholesterol diet (1.0 g/100 g, HC) and a high cholesterol diet supplemented with 2.0 g/100 g hawthorn fruit powder (HC-H). on atherosclerosis is limited to 3 rabbit studies (6-8)and 1 apoE-deficient (apoE−/−) mouse study (9). 2 and Table 1).HFD feeding did not affect plasma total cholesterol, triglycerides, HDL-C, glucose and blood cell counts (Supplementary Tables 2 and 3); however, plasma FFA and insulin levels were significantly increased in the 10%-HFD group compared with chow . Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS. The diet-induced atherosclerotic rabbit is an ideal model for atherosclerosis study, but temporal changes in atherosclerotic development in hypercholesterolemic rabbits are poorly understood. 4.1 Apparently this herb is also effective in improving lipid profile. Blood biochemistry is used to monitor progression of disease, before final evaluation including pathology of arteries and organs. Utilization of linseed in the feed of rabbits significantly affected the pH, protein, fat, textural and concentration of polyunsaturated fatty acids. Table 2 The fasting blood parameters and aortic wall area percent (mm 2) after 8 weeks of high cholesterol diet (HCD) fed rabbits treated with P. eldarica nut extract at dosages of 50, 100, 200 mg/kg compared with high control HCD fed rabbits (mean ± SD) In this study, high blood cholesterol and TG levels were induced by the high-fat/high-cholesterol diet (D12108C, 40% kcal fat with 1.25% cholesterol; Research Diet). Rabbits in the first group fed basal diet only and served as negative control. The aim of this study was to investigate the effects of a high-cholesterol diet in the presence and absence of statin on Cu-Zn-superoxide dismutase (Cu,Zn-SOD), malondialdehyde (MDA), protein carbonyl (PCO), and nitric oxide (NO) of blood and heart tissue, the antioxidant activity of serum paraoxonase-1 (PON-1), and on the blood lipid profile of rabbits. We found that the fat diet in rabbits impacts at the testicular level, causing the deregulation of the pathway governed by SREBP2. Their effects on lipid profile, lipid peroxidation and their aptitude to establish redox state between oxidants and antioxidants in body were evaluated in high cholesterol diet fed animal model. Group (III) (Cholesterol and Rosuvastatin treated): Rabbits were received rosuvastatin (2.5 mg/kg/day) and 2% cholesterol diet with tab water. The aim of this study was to investigate the effect of dietary supplementation with different sources of selenium and/or organic chromium on the growth performance, digestibility, lipid profile, and mineral content of hair, liver, and fore and hind limb of growing rabbits. Subsequently, the standard diet was enriched with the rabbit atherogenic diet containing 4.9% coconut oil, 1% cholesterol (w/w) E23113-23 (Ssniff, Germany) to a final concentration of 0.15-0.3% cholesterol for further 20 weeks. The pathological effects of a diet enriched with physiologically high levels of cholesterol, methionine and fat over a short period on the aorta are … The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion. By the end of the eighth week, blood and tissue samples were obtained for biochemical, histological, immunohistochemical, and in vitro analyses. Aortas and organs were then histologically analyzed. Effect of feeding diets high in monounsaturated fatty acids and α-tocopheryl acetate to rabbits on resulting carcass fatty acid profile and lipid oxidation Volume 64, Issue 1 C. Lopez-Bote (a1) , A. Rey (a1) , J. Ruiz (a2) , B. Isabel (a1) and R. Sanz Arias (a1) The robust rabbit model of atherosclerosis was generated by the methods established in our laboratory as reported previously [ 19 ]. Rabbits were fed a high fat/cholesterol (HFC) diet to induce atherosclerosis and NASH, and immunized with Fc-CETP6 vaccine. total cholesterol, LDL-cholesterol, TG, atherogenic . Eighteen rabbits were randomly divided into three groups (n = 6 for each). Rabbits in the second group fed basal diet mixed with 1% cholesterol and served as positive control. Professor of Anatomical Sciences. The aim of the present study was to assess the consistency of the biochemical profile of New Zealand White rabbits on standard diet from 3 to 6 months of age . It is used not only as a seasoning but also as a common a traditional medicine.19 However, a study on blood lipid profile of healthy The following list indicates the diameter size of the different lipoprotein classes (nm = nanometers): Chylomicrons: 75-1,200 nm. Rabbits are widely used in biomedical research and especially as animal models in atherosclerosis studies. [16] The drug was prepared immediately before use as a suspension in 5% . Few other animal models of atherosclerosis are available. can reduce the harmful effects of high-cholesterol diets.23 Acetic acid is the main ingredient of apple cider vinegar. glibenclamide (0.45 mg/kg) to donepezil (0.75 mg/kg) in a rabbit model of high fat diet- induced hypertension and hyperlipidemia. VLDL: 30-80 nm. In rabbits fed a high-cholesterol diet, we evaluated the effects of the combination therapy on atherosclerotic plaques, lipid profiles, blood glucose levels, liver and kidney functions. Rabbits were classified into four groups: control, nilotinib, HC, and HC + nilotinib groups. In this research, the effect of water extract and flour of DA tuber administration was examined on rabbits treated with high cholesterol diets. Japanese white rabbits were fed a high-cholesterol diet to induce sustained hypercholesterolemia, and each group of 10-12 animals was then sacrificed at 6, 12, 16, or 28 weeks. The study was planned in 5 distinct phases. The purpose of the first phase was to evaluate the effects of Trihoney on serum lipid profile and serum and testicular malondialdehyde (MDA) and antioxidant enzymes . In order to assess the impact of functional rabbit meat on human blood lipid profile, a study trial was conducted. However the water extract of DA can not maintain a normal blood lipids of high cholesterol treated rabbitsConclusion: Dioscorea alata flour has suggested to have anti-hyperlipidemia effect. high fat or ketogenic diet could lead to Obesity, high blood pressure, heart disease, diabetes, . Yet, rabbits fed cholesterol and either desiccated thyroid or Iodine similarly showed an absence of atherosclerotic lesions. Even those of us with only the fuzziest understanding of nutritional science have managed to grasp this basic fact: cholesterol bad.More specifically, we've been told for decades to avoid eating foods, like eggs, that are high in cholesterol, because they're terrible for our heart health — but that advice could soon be changing.. Every five years, officials from the USDA and the U.S . High cholesterol di-et (HCD) i.e. Blood samples were collected before and after 4 and 8 weeks of experimental diets for measurement of serum lipids, serum . Lipoprotein (a): 25-30 nm. 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